Type 2 Diabetes - How Do Oral Anti-Diabetic Medications Work?

The beta cells of the pancreas are responsible for the secretion of insulin, the hormone that facilitates the transport of glucose energy producers in the cells of the body. In Type 2 diabetes, a dysfunction of the insulin-producing cells combined with a decrease in individual cells insulin response, leads to an increase in blood sugar. The progression of beta cell dysfunction associated with increased insulin resistance is the usual indication for the use of oral antidiabetic drugs. With effective oral anti-diabetic, Hyperglycemia or elevated blood glucose levels can be corrected.When are anti-diabetes through oral drug indicated?According to APC Diabetes Care diabetes Guideoral should be launched if: fasting blood sugar level remains above 126 mg/dL (7mmol/L), oul' hemoglobin HbA1c, (HbA1c), the average concentration in red blood cells, is still above 7% four to six weeks after appropriate lifestyle changessuch as the food of regime change and an increase in physical activity have been in force.What are the available oral medications? 1 Insulin secretagogues, a group of oral drugs that stimulate the pancreas beta cells secrete more insulin. They also reduce sugar production by the liver and improve the combustion of sugar in the forms of energy can be used by muscle fibers. Insulin secretagogues can be subdivided into subclasses: a) sulfonylureas stimulate the secretion of insulin by the pancreas. (The most common examples of this sub-group include tolbutamide, tolazamide, chloropropamide, glyburide, glypizide and glimeperideb) are very useful in diabetic patients with irregular meal because of its ability to cause rapid stimulation of the pancreas to secrete insulin secretagogues hyperglycemia. The most common examples of this sub-group include repaglinide and nateglinide2. Insulin sensitizers improve the action of insulin in the body. This type of drugs can be divided into subgroups which may include: a) Biguanides. Metformin is the best-known form of biguanides. It inhibits the production of sugar in the liver and at the same time, an increase of the sensitivity of the muscle and fat to stimulation of the insulineb) Thiazolidinediones (TZDS) are a group of medications that increase the sensitivity to insulin in muscle fibers and fats.(The most common examples of this group include the rosiglitazone (Avandia) and poiglitazone (Actos) c) alpha-glucosidase inhibitors actively inhibits the absorption of carbohydrates in the intestines by blocking the enzyme which facilitates the absorption of carbohydrates. One of the most common problems associated with this type of diabetes medications is the development of problems such as cramping, bloatedness, flatulence, abdominals and sometimes gross of diarrhea. (Are the most common examples of alpha-glucosidase inhibitor acarbose and miglitold) Dipeptidyl peptidase IV increases insulin secretion by inhibiting the enzyme that degrades incretins, a special hormone that trigger the secretion of insulin. The example best known inhibitors of dipeptidyl peptidase IV is sitagliptinAlthough that many people find that they can bring their blood glucose levels in the normal range by making changes to their diet, doctors often assume that dietary changes not the problems of sugar in the blood of their patients with Type 2 diabetes and prescribe one or more of the above drugs. These drugs have limited power to lower blood glucose levels in the normal range. Food control is still needed to reduce your blood glucose within the normal range.